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Paclitaxel-induced hyperexcitability of DRG neurons is linked to the inhibition of KCNQ2 and systematic administration of a selective blocker of KCNQ2 (XE-991), induced mechanical allodynia and loss of IENFs (Wu et al., 2022)

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Although current pharmacological regimens have achieved some success in relieving symptoms, most of the existing drugs are directed at specific pathologies, and it is often difficult to consider multiple intertwined metabolic and immune signaling pathways in the patient’s body